Grant Challen, PhD
Associate Professor Department of Medicine - Oncology Division - Molecular Oncology Section
Dr. Challen’s work in understanding the molecular regulation of hematopoietic stem cells is motivated by his desire to improve the lives of patients afflicted with hematopoietic disorders. His ultimate career goal is to see the implementation of meaningful discoveries in basic biology help drive novel clinical outcomes. He believes that deciphering the contribution of epigenetic factors in hematopoiesis could ultimately lead to novel therapeutic approaches for a wide range of patients.
Aberrant epigenetic marks, such as DNA methylation and histone modification patterns, are widely reported in human hematopoietic malignancies, but the pathological consequences of these marks remain to be defined. Moreover, genetic mutations in a number of critical components of the epigenetic machinery have recently been discovered in diseases such as acute myeloid leukemia, myelodysplastic syndromes, and T-cell leukemia / lymphoma. There is mounting evidence for the importance of epigenetic mechanisms in the regulation of stem cell function. This area of study represents one of the next major fields of stem cell biology. As a post-doctoral fellow at Baylor College of Medicine, Grant identified a crucial role for the DNA methytransferase enzyme Dnmt3a in hematopoietic stem cell self-renewal versus differentiation fate decisions.
In his independent research laboratory at Washington University in St. Louis, Grant has extended these studies into mouse models of hematopoietic transformation and shown that loss of Dnmt3a in the bone marrow leads to the development of myelodysplastic syndromes after long latency. The observation that hypomethylating agents such as decitabine can induce a clinical response in a subset of patients highlights the importance of targeting epigenetic marks in cancer therapy. However, cancers are driven by both global and specific epigenomic dysregulation and the key is to restore the abnormal marks while retaining the normal distribution. We are now developing molecular tools for locus-specific epigenomic remodeling. As a member of the Siteman Cancer Center, Dr. Challen is dedicated to a career in academic cancer research.

Education
- B.Sc (Hons), Central Queensland University, Rockhampton, QLD, Australia
- PhD, The University of Queensland, Brisbane, QLD, Australia (Mentor: Professor Melissa Little)
- Postdoctoral Fellow, Baylor College of Medicine, Houston, TX (Mentor: Professor Margaret Goodell)
Awards
- 2005 - Queensland Premier's Award for Health and Medical Research
- 2006 - National Health and Medical Research Council CJ Martin Training Fellowship
- 2008 - Dan L. Duncan Cancer Center Symposium "Best Oral Presentation"
- 2009 - Center For Cell and Gene Therapy Symposium "Best Oral Presentation"
- 2010 - NIH K99/R00 Career Development Award
- 2010 - American Society of Hematology ASH Scholar Award
- 2010 - Dan L. Duncan Cancer Center Symposium "Best Oral Presentation"
- 2010 - American Society of Hematology Joanne Levy Memorial Medal
- 2011 - Forbeck Scholar Award (William Guy Forbeck Research Foundation)
- 2012 - Alex's Lemonade Stand "A" Award
- 2012 - Children's Discovery Institute Interdisciplinary Research Award
- 2013 - Edward Mallinckrodt, Jr. Foundation Scholar
- 2014 - American Society of Hematology Junior Faculty Scholar
- 2015 - Sidney Kimmel Foundation Scholar Award
- 2015 - V Foundation V Scholar Award
- 2018 - Leukemia and Lymphoma Society Scholar Award
Professional Societies & Organizations
- 2005—present - International Society for Stem Cell Research (ISSCR)
- 2009—present - American Society of Hematology (ASH)
- 20012—present - Society for Hematology and Stem Cells (ISEH)
Join Our Team
Challen Lab actively recruits motivated and enthusiastic post-docs, Ph.D. students and technicians to work and assist on projects related to stem cells, epigenetics and leukemia research!
Challen Lab trainees have a 100% success rate for acquiring awards and fellowships!
Please send CV/resume, references, and research statements to Dr. Grant Challen